Simultaneous LC–MS–MS Analysis of Valsartan and Hydrochlorothiazide in Human Plasma
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چکیده
منابع مشابه
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15 صفحه اولSimultaneous Determination of Valsartan and Hydrochlorothiazide in Tablets by RP-HPLC
A simple, reproducible and efficient reverse phase high performance liquid chromatographic method was developed for simultaneous determination of valsartan and hydrochlorothiazide in tablets. A column having 200 x 4.6 mm i.d. in isocratic mode with mobile phase containing methanol:acetonitrile:water:isopropylalcohol (22:18:68:2; adjusted to pH 8.0 using triethylamine; v/v) was used. The flow ra...
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Hypertension or high blood pressure, sometimes called arterial hypertension, is a chronic medical condition in which the blood pressure in the arteries is elevated. This requires the heart to work harder than normal to circulate blood through the blood vessels. The main factor that characterizes a rational drug combination is a synergistic action without side effects. In 2009, the US Food and D...
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An accurate, precise and reproducible reverse-phase stability-indicating HPLC method has been developed and validated for the simultaneous estimation of Amlodipine, Hydrochlorothiazide and Valsartan in combined dosage form. Separation was achieved using Phenomenex ODS 5μ, C18 column (250×4.6mm) and ACN : Methanol : 1% Triethylamine Buffer (39:26:35) as mobile phase which shows sharp and resolve...
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A new, simple, precise and stability-indicating UPLC (Ultra Performance Liquid Chromatography) method was developed and validated for the simultaneous determination of anti-hypertensive drug Valsartan (VAL) and Hydrochlorothiazide (HCTZ) in combined dosage forms. The method was developed using Kromasil eternity C-18 column (50 mm×2.1 mm, 3.5 μm) with isocratic elution. Triethylamine buffer (0.1...
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ژورنال
عنوان ژورنال: Chromatographia
سال: 2009
ISSN: 0009-5893,1612-1112
DOI: 10.1365/s10337-009-1074-3